Nonsteroidal anti-inflammatory drugs (NSAIDs)

NSAIDs block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced. Since the prostaglandins that protect the stomach and support platelets and blood clotting are also reduced, NSAIDs can cause ulcers in the stomach and promote bleeding. NSAIDs are used primarily to treat inflammation, mild to moderate pain, and fever.